ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2017, Vol. 48 ›› Issue (2): 207-213.doi: 10.11843/j.issn.0366-6964.2017.02.003

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The Role of Wnt Signaling Pathway in the Flatworm

WANG Zhi-xin1,2, ZHANG Yan-yan1, LU Ping-ping1,3, MA Xun3, WANG Zheng-rong1* , BO Xin-wen 1*   

  1. (1.Xinjiang Academy of Agricultural and Reclamation Science, State Key Laboratory for Sheep Genetic Improvement and Healthy Production, Shihezi 832000, China;2.College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;3.Shihezi University, Shihezi 832000, China)
  • Received:2016-09-21 Online:2017-02-23 Published:2017-02-23

Abstract:

High conserved Wnt signal transduction pathway regulate multiple aspects of animal development, including growth and development, disease, aging, death etc. In this review, we summarize the role of Wnt signaling pathway in flatworm (planarian, tapeworm and trematode). Wnt signaling pathway accurately guide regeneration, regulate antero-posterior (AP) axis patterning and maintain genes gradient expression along AP axis in muscle cells and stem cells in planarian. Wnt signaling pathway regulate the development of proglottid in tapeworm, academics studied the function of wnt1, wnt2, wnt4 and wnt5 genes in the trematode. There are still many questions to be settled and prospects in Wnt signaling pathway in flatworms.

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